OverPicture is a macOS Safari App Extension that allows you to play any HTML5 video with the new picture-in-picture mode.
Press the play/pause button in any web video player in Safari and then in the toolbar PIP button and the video will start playing in picture-in-picture over your windows. And it will even embed custom buttons in some video players like YouTube.
Note: You have to open the app and then enable the Safari app extension in Safari preferences.
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