MacVector
MacVector
18.2.0
5.0
0.0
MacVector free download for Mac

MacVector18.2.0

20 October 2021

Sequence analysis for molecular biology.

Overview

MacVector is the leading package of kind for Mac and an ideal solution for researchers who want a simple but comprehensive desktop sequence analysis application. MacVector provides sequence editing, primer design, Internet database searches, protein analysis, sequence confirmation, contig assembly capabilities, multiple sequence alignment, phylogenetic reconstruction, coding region analysis, and a wide variety of other functions. With MacVector you can view the results of any analysis in graphical or text format.

All analysis, editing, and display functions are contained within a single application, so not only will you find MacVector remarkably user-friendly but you'll also save time whether you're exploring gene relationships, predicting coding sequences, or conducting cloning experiments. You'll be amazed at how quickly you can flow from task to task with just a few mouse clicks. Furthermore, collaboration with colleagues will be easier than ever because MacVector lets you customize graphic results and export them for high-quality printing.

What's new in MacVector

Version 18.2.0:
Align to Reference Enhancements
  • The Align to Reference alignment algorithm has been overhauled to do a much better job handling larger numbers of gaps in the alignment between a reference sequence and a read. Previously, for the standard alignment algorithm, more than 5 or 6 consecutive gaps in either reference or read would be poorly resolved. Now 20-40 consecutive gaps, such as might appear in CRISPR experiments are handled with ease, depending on settings. However, if you are expecting introns when aligning e.g. mRNA sequences versus a genome, you should still use the cDNA Alignment option which will also take splice site consensus sequences into account. The alignment algorithm has been further optimized for speed and is now 2-10 fold faster depending on the sequences being aligned. In addition, the Sensitivity setting can now be lower due to the enhanced consecutive gap detection, which also speeds up calculations. When aligning ABI chromatogram data, or plain sequences, the Map tab now graphically displays the "trimmed" regions at either end of the sequences making it far more obvious when there is only partial alignment between two sequences. This does not apply to NGS reads where it is impractical to view potentially millions of reads in the Map tab. There is a new Remove Gaps context-sensitive (right-click) menu option that deletes residues in reads that correspond to a gap in the consensus sequence. This can clean up noisy assemblies where a low percentage of reads have extra residues inserted leading to a lot of gaps in the consensus sequence and a very cluttered display.
Context Sensitive Hamburger Menus
  • Many of the views and windows in MacVector have context-sensitive menus available when you right-click (or -click) in them. To make the availability of these options more obvious, these views now contain a "hamburger" button (three parallel horizontal lines) that displays the same context sensitive menu when clicked on. So, if you see the button on the toolbar, click on it to see what additional options are available.
Importing of Primer Databases in TSV or CSV Format
  • You can now directly import primer data into a MacVector Primer Database (.nsub) file. First, prepare your data in an Excel or Numbers spreadsheet with three columns - "Name", "Sequence", "Comment". Then export the data (or Save As…) in Tab Separated Values format or Comma Separated Values format. Open the file with TextEdit, select all the rows of text, Edit | Copy, switch to MacVector and select File | New From Clipboard. This functionality replaces the old Primer Converter utility which no longer runs on modern macOS systems.
Miscellaneous Enhancements
  • To reduce clutter in the Assembly Project window toolbar, all of the assembly algorithms have been consolidated into a single Assemble toolbar button with a dropdown menu.
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App requirements: 
  • Intel 64
  • Apple Silicon
  • OS X 10.11.0 or later
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