Wine allows OS X users to run Windows applications.
Note: this listing is for the official release of Wine, which only provides source code. If you want a version of Wine that is packaged specifically for OS X, then use Winebottler, available here.
Wine (originally an acronym for "Wine Is Not an Emulator") is a compatibility layer capable of running Windows applications on several POSIX-compliant operating systems, such as Linux, OS X, and BSD. Instead of simulating internal Windows logic like a virtual machine or emulator, Wine translates Windows API calls into POSIX calls on-the-fly, eliminating the performance and memory penalties of other methods and allowing you to cleanly integrate Windows applications into your desktop.
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There are certain things WINE will never be able to do, seeing as Microsoft uses a great deal of proprietary code in Windows. Microsoft's DirectX is proprietary. Apparently, getting WINE or any of the virtualization systems to work with software requiring DirectX 11 or 12 isn't happening. That's one reason the number of recent games that run in WINE or virtualization is very limited. I've ended up using Apple's kindly provided Boot Camp instead, which runs the latest Windows 10 perfectly (not that Windows 10 is perfect, please note). Add on Paragon's excellent utilities for APFS/HFS+ and NTFS compatibility and you're golden.