Tweetbot

Tweetbot is a full-featured OS X Twitter client with a lot of personality. Whether it's the meticulously-crafted interface, sounds and animation, or features like multiple timelines and column views, there's a lot to love about Tweetbot.

Features

• Multiple Timelines. Quickly switch between your lists as your main timeline.
• Multiple Windows and Columns. Display timelines from different accounts side by side.
• Notification Center support.
• Beautiful Retina graphics.
• Mute filters lets you block messages from users without unfollowing them. You can also mute hashtags and specific keywords.
• Sync timeline position, direct message read statuses, and mute filters between your Mac, iPhone, and iPad via iCloud.
• Support for multiple services like Pocket, Instapaper, Readability, CloudApp, and Droplr.
• Save drafts, add locations and POI's, attach photos/videos, manage your lists, and much more.

• Added support for posting up to 280 character long Tweets
• Blocking users now prevents Tweets from those users showing up in Tweet search and Tweet replies