AppKiller lets you close all your open apps, with the fuss of going through them one-by-one. Do you want to be able to do with a single click? Or - even better - with a single... keyboard shortcut? Look no further!
Easy-to-use: App Killer sleeps unobtrusively in your status bar and waiting for... orders
Ultra-fast: Killing all your open application will take no more than... milliseconds
Cmd+Shift+K: And that's all it takes to instantaneously kill all your open apps--really!
What's new in AppKiller
Update for macOS Big Sur (11.0)
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Although there are other free ways to force kill apps, it can be useful to do this with a single key. Meaning this app does what it claims to do. :)
A simple UI is something I always find important and this app fits the bill.