I was a user of GlimmerBlocker before, but that stopped working correctly on El Capitan, so I switched to uBlock, but that's (a) an in-browser blocker, and (b) deprecated anyway for Safari. So back to Adguard. I really appreciate the system-wide approach with the desktop app, and the price for a life-time license is actually fair. The new version works flawlessly on 10.11.4, and it's way better than just the browser extension… better than Adamant, Ka-Block etc. as well. (Don't like the new API with 50,000 rules maximum at all.) Love the automatic filter loading. If you're serious about ad-blocking, Adguard should be the thing for you. The only thing that's missing is the ability to add user-defined filter-subscriptions by URL. Don't know about js, but that seems to be missing too. But it all seems to be in the works. Bottom line: Great adblocker, and if you're looking for a system-wide blocker, it's the only one you should consider. PS: Reek's anti-adblock killer works flawlessly in Adguard; I always had problems with that in uBlock (probably because of the old Safari API).