Behind the scenes, Open-With Manager works in a way that's quite similar to Service Scrubber. And to be perfectly honest, Open-With Manager is in fact Service Scrubber's well-hidden, slightly older twin brother. That's why the restrictions detailed for Service Scrubber in this blog entry apply to Open-With Manager as well. When running on Mac OS X 10.5 or later, Open-With Manager will not edit signed applications.
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