RouteSplit is a AppleScript Studio application for Mac OS X. With RouteSplit you can add a static route, test it and optionally install a launchd startup script in your system in order to preserve the route settings after reboots.
A very handy and intuitive app for bypassing my VPN when I'm trying to get to sites that ban access from VPNs. Does exactly what I need it to do without the hassle of having to manually set up static IP routes in Terminal.