1. User who use a lot of tabs will notice that the memory usage is just skyrocketing, the "Google Chrome Helper" processes are just piling up and never reduce their footprint even after closing lots of tabs and or windows. I call this a major memory leak. 2. The activity of the Google Software Update Daemon borders on malware characteristics. How many outgoing connections this things wants to establish is just beyond anything remotely reasonable. I wonder what this software is actually transmitting so feverishly. 3. When restarting Chrome it automatically loads all previously opened tabs instead of incrementally as you click on them as Firefox does - which is way smarter. 4. Power users will miss the convenient bookmark bar on the left. I find it cumbersome without. That said, it works fast and stable - for a while - until it has to be restarted because of issue #1 (see above).