Plugsuit shows some promise. What it should be really useful for is turning on/off such things as SafariStand, Keyword Manager and other SIMBL based plugins to isolate bugs. And for the most part it does this.
To disable SIMBL, go to /Library/Input Managers/ and zip up/throw SIMBL in the trash.. THEN restart and install PlugSuit. There. Fixed that for you.
I have found some issues.
* PlugSuit doesn't always run at login time. Meaning 'Hey, WhereTF is SafariStand?? *Sigh* Go to Preferences and fire it up.
* SIMBL plugins load sluggishly. Run iPhoto.. huh? Where's KeyWo... oh. There it is.
* Some plugins don't work at all or load rarely. I'm looking at you, Blurminal.
My advice is to keep a zipped copy of SIMBL in where you found it. However, I am beginning to like Afloat.
If the author adds a menu item to tell us that PlugSuit is 'on' that might be a nice think to do. Also, finer control of keyboard shortcuts so as not to conflict with Butler, MercuryMover, etc. In other words, better status display and finer control of prefs.