If the font would normally show up separately in the Font menu, it should be selectable in FontCard's version of the Font menu. As OS X ships, Helvetica Neue bold and italic aren't selectable in most applications, only Helvetica Neue. You may be referring to algorithmic variants (i.e. creating bold by drawing the characters thicker), which Cocoa and some Carbon OS X applications do not support. However, most Carbon applications don't let you pick fonts marked as variants of other fonts if they aren't available directly - for example, if they use AppendResMenu to create their font menus - most of those that do (such as Adobe applications) only work that way because they're using their own type engine. (Ironically, so few applications use the Apple-recommended CreateStandardFontMenu - which does display variants - that FontCard doesn't support it.) It's not so simple and FC does its best; but if there's an application in which FC is doing the wrong thing, please report it to Unsanity.