MILOWERX  Sketchbook Pro (SBP) kicks major butt. Whether you're a seasoned pro or a digital newbie, the simple-to-use interface will have you up and drawing in 10 minutes. Let's see you do that with Photoshop! One other reviewer suggested that ArtRage was cheaper so you should buy that. I disagree. ArtRage is a fine tool but all it does is paint. Anyone who can paint can draw but not everyone who can draw can paint so I would suggest that you get SBP instead because it allows you to draw and paint. ArtRage's pencil tool is terrible whereas SBP's pencil tool is without a doubt the closest thing to the real lead and rubber original you will find on the market. Painter, Photoshop, Paint Shop Pro, Artrage, Twisted Pixel and any other graphics app out there can't do pencil well. The only other one that comes close is Scribble and that's not advanced enough to warrant using it professionally.

SBP does it right out of the box... and the new version is even better than the previous versions because it now has a ruler and an ellipse tool as well as custom brushes with which you can create textures to draw with and save.

All in all if you want to create amazing art with your computer look no further than Sketchbook Pro 2010. It's easy to use, robust and I dare you not to fall in love with it's interface.  
(Version 4.0)