DESTERWALLABOO Not sure why you have to have a powerful AGP card or have 3D turned off to use SheerVideo Pro... that doesn't make any sense at all!
Anyway, with that said, we use this codec daily in our regular workflow. We rarely render out in any other codec except for final delivery. Keeping animation files and such in a smaller, pristine lossless format is priceless. When we changed over to Sheer from using Animation codec we literally saved over 2TB of file size by simply converting our existing Animation codec files to Sheer. Also, Sheer supports 10-bit color space... something Animation doesn't support.
(Version 2.4.5.1)