TRAHE  Perl Dev Kit is a great tool for doing cross.platform Applications, though you will need to install on every single Platform andbuild on them,

the integrated PPM Package Manager, makes installing and maintaing Modules a snap, but well the PPM packages are quite less compared to the complete CPAN, anyway this helps a lot to keep an eye on dependencies and make sure the App will work in (special) Windows, too.

I rather like the debugging in Komodo IDE

I miss some kind of simple GUI IDE, but well this is merely the point of Perl ..., since there are many, and very OS dependant GUIs  
(Version 7.1)