CASCADEHUSH  Works okay with a Silvia Multinavigator, with the serial adapter cable (which I had to buy separately) and an Aten UC-232A Serial to USB adapter.

I was able to get a realtime fix.

I was not able to use other functions like uploading or downloading waypoints.

But it's a nice start.

I'll keep playing with it, I don't know if I really have enough need to pay for it. Although I think it's a reasonable price.  
(Version 3.40.2)

XTAL  Did anyone test it with a Garmin USB device? Still no USB support in this version?  
(Version 3.40.1)

AMAGINE  This type of application was wonderfull way back in the day when gps to computer interface was new. This app is a sad reflection on the poor status of gps-gis interfaces on the macintosh platform.  
(Version 3.40.1)

BRETTD  Doesn't support any USB-based devices.  
(Version 3.40b7)

RJBAILEY  I'm glad to finally see a Mac OS X version of this program. I got to love it in the days of OS9, but feature-wise it's the same as it was years ago. I hope the developers keep this baby alive.  
(Version 3.40b3)