OSOS10 I finally upgraded from v5.2 to v6.0.3. Indeed the new version is a major improvement. Particularly in the user interface, a vastly improved input/output formats, graphics and more (this is important when accounting for the fact that the set of improvements during the shift from v4.X to 5.X was essentially an empty set). Thus I find Mathematica 6.0.3 working smoothly. The only drawback is that under OS10.5.5, whenever Mathematica is running, my MacBook doesn't sleep and hence my battery is being drained. I hope that this will be fixed soon (before I have to purchase a new one).
(Version 6.0.3)