I can confirm that Nikon Scan doesn't work on Leopard. The application starts but the scanner isn't recognised. Hence one doesn't get the window where you're supposed to launch the scan. I will also add that, ever since the beginning, I have had many problems with this software, even on a Power PC. In conclusion, Nikon is far from being Mac friendly. If you can,just avoid it.
Maruzzo
[Version 4.0.2]
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Nikon Scan
Maruzzo