I have used both Knox and Espionage, and both are easy to use and work well. Espionage allows encryption for on-the-fly encryption of folders or disks without creating a disk image. This works better for many situations, such as encrypting you mail or documents folder. Tech support was very responsive, and answered my issue within hours. They had already issued a fix for the problem in a new version.
[Version 2.8.12]
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+2
Espionage
dd08 reviewed on 30 Jun 2011