From my perspective it's very difficult to think of anything positive to say about TuneUp. With the current versions of TuneUp and iTunes TuneUp crashes every time it launches. I have had a number of tickets with Support but these have achieved absolutely nothing. Judging by the number of posts on their forums I am one of many many people to have this and other problems. The list of reported problems is extensive.
Support is poor - very rarely is there anything from them on the forums other than "I have issued ticket .....". Users are not kept informed.
I bought a Lifetime Gold Membership which was supposed to cover me. Tuneup changed the app slightly, adding an extra option, and informed Gold Members they would have to pay more cash to access the complete package. This caused uproar on the forums - all to no avail.

I would avoid this program like the plague.