I, too, can't seem to be able to get it to work on OSX 10.6.3. I have tried deleting every file related to any prior versions of MacSword (the Library files, etc.), and on a fresh download and install, I still get the same "MacSword quit unexpectedly"...incessantly. On the "report" that it offers to send to Apple, it says the following:

Date/Time: 2010-04-18 19:27:44.413 +0300
OS Version: Mac OS X 10.6.3 (10D573)
Report Version: 6

Interval Since Last Report: 557563 sec
Crashes Since Last Report: 11
Per-App Interval Since Last Report: 4 sec
Per-App Crashes Since Last Report: 10
Anonymous UUID: AAB26C49-E9EF-48CF-81B5-AF9994C2C79F

Exception Type: EXC_BAD_ACCESS (SIGBUS)
Exception Codes: KERN_PROTECTION_FAILURE at 0x0000000000000000
Crashed Thread: 0 Dispatch queue: com.apple.main-thread

Application Specific Information:
objc[20142]: garbage collection is ON

Thread 0 Crashed: Dispatch queue: com.apple.main-thread
0 org.crosswire.MacSword 0x0006f8c7 sword::SWMgr::augmentModules(char const*, bool) + 1351
1 org.crosswire.MacSword 0x0001a1c3 -[SwordManager reInit] + 869
2 org.crosswire.MacSword 0x0001a9c1 -[SwordManager initWithPath:] + 219
3 org.crosswire.MacSword 0x0001a8cb +[SwordManager defaultManager] + 82
4 org.crosswire.MacSword 0x00008996 -[AppController applicationWillFinishLaunching:] + 117
5 com.apple.Foundation 0x97a811cb _nsnote_callback + 176
6 com.apple.CoreFoundation 0x94cf73f9 __CFXNotificationPost + 905
7 com.apple.CoreFoundation 0x94cf6e2a _CFXNotificationPostNotification + 186
8 com.apple.Foundation 0x97a76098 -[NSNotificationCenter postNotificationName:object:userInfo:] + 128
9 com.apple.Foundation 0x97a83475 -[NSNotificationCenter postNotificationName:object:] + 56
10 com.apple.AppKit 0x92978f0d -[NSApplication finishLaunching] + 493
11 com.apple.AppKit 0x92978909 -[NSApplication run] + 79
12 com.apple.AppKit 0x92970c85 NSApplicationMain + 574
13 org.crosswire.MacSword 0x000070aa start + 54


I don't understand any of this, except that I see there is a thread crashing. My system info is as follows:

2009 MB Pro Unibody
OSX 10.6.3
4 MB RAM

If you need more info, will gladly supply it. I was very happy with MacSword prior to updating to Snow Leopard and having these problems.