ROBOTANK iCab is a fantastic browser. I'm using it as my default browser currently, though I tend to switch occassionally between it and OmniWeb, the only other Mac browser that has comparable advanced features and bears comparison to iCab (except perhaps Opera, which will never really be a Mac browser for me). In any case, iCab is currently my pick because it has both OmniWeb's features and Safari's performance. Running in 64-bit under SL and using the system WebKit framework, iCab is blazingly fast and clearly outperforms OmniWeb. Needless to say, iCab is extremely feature-rich and allows you to customize just about every aspect of your browsing. The only real stumbling block I have ever encountered with iCab is that locating and understanding all of its features and settings can be a little bit difficult and/or time consuming. For instance, using the filter manager to set a simple domain preference (say, user-agent string for me.com) takes far longer than it does with OmniWeb's site preferences. Another example: iCab's JavaScript settings offer numerous options, the meanings of which may not be apparent to some users (i.e. how to block pop-up windows) and could benefit from more detailed documentation. On the other hand, the trade-off in both cases is superior control. iCab's filter manager offers more fine-grained control (i.e. not restricted to second-level domains only) than OW's site prefs, and iCab allows more control over JavaScript than OW. If you're willing to take a bit of time to sort through all of iCab's myriad options, you'll find an extremely powerful and customizable browser that blows Safari and Firefox out of the water. Note that iCab also works with the most essential browser plugins, 1Password and Click-to-Flash. Finally, if you want more thorough ad-blocking than comes with iCab's included filter examples, check out the additional filters on the Downloads page of the iCan website (I've found that GlimmerBlocker doesn't play nice with iCab; I have no idea why).
(Version 4.7)