PRIMITIVEHUMAN This is a great improvement to the original Comic Life with the addition of an image editor, reusable styles, more fonts, better file/picture browser, excellent isight camera integration, and a bunch of cool starter templates. You can also use your own vector graphics by dragging them directly into the spray/theme panel. Exporting can be done directly to Flickr, Email, HTML, iPhoto, iWeb, PDF or Images. The HTML export option uses some sort of variation of Lightbox, I believe.
(Version 1.0.1)