EASER  I looked at Wine and any related products. Frankly, I don't care if CrossOver Mac is using that as the basis of its software. I find CrossOver Mac's interface to be very user friendly. If they've repackaged Wine, so be it; it still works well for me. I need to learn the PC version of MS Office, and I much prefer a program like COM over having to spend a fortune on both Windoze and MS Office. MS Office seems to work just fine with COM; indeed, I can drag and drop files onto the Windoze Office icons, and the files open. Pretty handy. I've also found customer support to be very good.   
(Version 7.0.2)

HODAGACZ  I tried Crossover Mac when it first came out, and was pretty impressed. Then they released Crossover Games and it is amazing. I can run Access (not my first choice of DB) perfectly smoothly, and this is the non-Office optimized version! I haven't tried 7.x yet, but I would be very surprised if it wasn't as polished. I have used Darwine, and for personal machines where I have the spare time to fiddle with it, it's fine. However for work machines, I prefer Crossover.  
(Version 7.0.2)

STAGNENT MIND  now if this app allows you to run Wnidows peograming without installing windows don't that allow trojans and other bad things can run in your Mac ?  
(Version 7.0.2)

JOHN1620B  Although the compatibility might not be as good, for an easier to use and free alternative (an OS X build of Wine), go here:

http://www.kronenberg.org/darwine/  
(Version 7.0)

AKROBAT  Old Wine in new bottles... literally, since this is just a jazzed-up version of that user-unfriendly software.

It can run a few apps and mostly takes a god awful long time just to get one running well.

Good for gamers and other people who like to play about perhaps, but for those who need the job done, the only serious choices are Parallels (Intel) or VPC (PPC).  
(Version 6.2.1)

JOEL.SCHMIDT  Moderately runs Phantasy Star Universe: Ambition of Illuminus, which is a DirectX 9 game  
(Version 6.2)

JOHNODD  Don't like crossover.

Still only supports direct x 8.1 applications so no recent games will run lame really lame   
(Version 6.2)

JETFIREDX  Still doesn't support the one app I need it for - fragMotion. Application closes after showing its splash screen. I saw no improvement with speed to the point that the installer works and the application launches. (But this was pretty fast already so I am not expecting anything better.)

I would love to use this instead of Parallels and Bootcamp, but until the compatibility improves there is just no way I can.  
(Version 6.2)

REPEATER75  Tested on mid-2007 blackbook. Runs Steam / Team Fortress 2 BETTER than with Bootcamp. For some reason, all the graphical glitches with Boot Camp are gone, save one new one (chat text is garbled). I am so glad I tried this out as I am now going to ditch my bootcamp partition and go with Crossover for my Steam gaming experience. Great product just keeps getting better. Its not the answer for everything, but gaming performance for me and my macbook far outshines any other solution I've tried on this hardware including bootcamp, parallels and vmware. I've bought the linux crossover product in the past before I went over to the Mac and Codeweavers has really taken their product to another level with the help of the hardworking WINE devs.  
(Version 6.2)

IGAUCHO  This update brings some much needed improvements. I really like having the application icons in the Dock now (somewhat similar to Parallels and VMWare Fusion), and it's now so much faster at launching apps! Good job guys!

Crossover may not support every Windows application out there, but those that it does support work really well. Much cheaper than buying a copy of Windows if you just have a handful of applications you need to use. It's also easier than trying to setup and install WINE yourself in the Terminal.

Now if only there were an option to turn off that annoying window asking you if you want to install applications... You close it and it comes back when you switch back to Crossover from another application.  
(Version 6.2)