I have yet to find an application as good as foobar2000 on a mac, but I quite like this.
I feel like saying the emperor has no clothes, but is no one else aware of the drawbacks of iTunes? It's unusable for large collections, especially ones that are organized by folder.
Don't even try to use your 100gb+ classical collection in iTunes' oppressively metadata-driven management.
Enqueue doesn't fix these problems, but it's by far my favorite little OS X music player anyway. It's lightweight, clean, and emulates the foobar2000 style interface.
If the author of enqueue added an option to browse by folder directory instead of metadata (artist, genre, album), I would be ecstatic.